Oradexon 0.5mg Tablet

Uses of Oradexon 0.5mg Tablet

Treatment of -

• Inflammatory conditions
• Autoimmune conditions
• Covid-19.

How does Oradexon 0.5mg Tablet work?

Oradexon 0.5mg Tablet is indeed a steroid medication with anti-inflammatory and immune suppressant properties. It works by replenishing the levels of corticosteroids (such as cortisol and aldosterone) in the body during deficient conditions, allowing the body to function properly.

Additionally, Oradexon 0.5mg Tablet reduces the release of specific chemicals called prostaglandins in the body, which are responsible for causing inflammation, pain, irritation, and swelling. By inhibiting the production of these chemicals, Oradexon 0.5mg Tablet helps alleviate allergic and inflammatory conditions within the body.

Side Effects of Oradexon 0.5mg Tablet

The following are common and rare side effects associated with Oradexon 0.5mg Tablet :

Common side effects may include:

• Headache
• Dizziness
• Spinning sensation
• Increased sweating
• Acne
• Skin rash
• Bruising
• Nausea
• Stomach pain or discomfort
• Increased appetite
• Changes in vision
• Feeling weak or tired
• Slow wound healing
• Skin thinning
• Fits (seizures)
• Difficulty in swallowing
• Sore throat
• High blood pressure
• Fluid retention
• Swelling and weight gain in the body and face
• High blood sugar levels with excessive thirst
• Muscle weakness and wasting
• Bone thinning with an increased risk of fractures
• Raised pressure in the eye
• Cataracts
• Irregular or lack of menstrual periods
• Increased susceptibility to infections

Rare side effects that require immediate medical attention:

• Signs of an allergic reaction (e.g., skin rash, itching, blistering, peeling of the skin, swelling of the face, lips, mouth, and throat, leading to breathing difficulties)
• Severe skin rashes with blistering and peeling of the skin
• Feeling depressed, experiencing suicidal thoughts, mania, mood swings
• Anxiety, sleeping problems, problems in thinking, confusion, memory loss
• Hallucinations, strange thoughts, behavioral changes
• Signs of pheochromocytoma crisis (e.g., headaches, sweating, palpitations, hypertension)
• Signs of adrenal suppression (e.g., swelling and weight gain around the trunk, excessive hair growth in women, muscle weakness and wasting irregular or missed periods, stunted growth in children, purple stretch marks on the body, changes in protein and calcium levels in the body)

It is important to promptly contact your doctor if you experience any of these rare side effects or if you have concerns about any of the common side effects while taking Oradexon 0.5mg Tablet.

Quick Suggestions:

Diet & Lifestyle for Allergic or Inflammatory Conditions:

• Consume antioxidant-rich foods like blueberries, tomatoes, cherries, squash, and bell peppers.
• Include probiotic-rich foods to support the immune system's resistance to allergies.
• Eat foods rich in quercetin, such as apples, cherries, spinach, broccoli, and blueberries.
• Include seasonal fruits, vegetables, whole grains, healthy fats, and fish in your daily diet.
• Limit consumption of potential allergens like dairy products, soy, eggs, and nuts.
• Limit intake of foods high in sugar that may exacerbate inflammation.
• Reduce stress and maintain a regular sleep schedule.
• Avoid processed meats, refined carbohydrates, sugar, trans fats, and alcohol, as they can worsen inflammation.

Diet & Lifestyle for COVID-19:

• Wear a mask when around others to prevent the spread of illness.
• Take care of your mental health through therapy, yoga, and meditation.
• Maintain social distancing and avoid social gatherings.
• Practice good hand hygiene by washing hands with soap and water or using hand sanitizer.
• Clean and disinfect surfaces regularly.
• Gargle with salt water and inhale steam for potential benefits.
• Avoid sharing personal items contaminated with bodily fluids.
• Avoid sharing needles or medical devices to prevent the spread of viruses.
• Consume a well-balanced diet with vitamin and nutrient-rich foods to support the immune system.
• Avoid raw meat or eggs and opt for cooked options.
• Eat bland, low-fat foods if experiencing nausea or vomiting.
• Engage in activities that reduce emotional and physical stress.

Regarding Oradexon 0.5mg Tablet :

• Oradexon 0.5mg Tablet is a type of steroid medication used to treat inflammatory conditions, allergies, and autoimmune conditions.
• Follow the prescribed dosage and complete the full course of treatment.
• Do not increase the dose or abruptly discontinue without consulting your doctor.
• Inform your doctor if you are pregnant, planning pregnancy, breastfeeding, or have any medical history.
• Side effects of Oradexon 0.5mg Tablet can vary based on dosage and duration of treatment.
• Oradexon 0.5mg Tablet tablets should not be used during pregnancy as they may affect fetal growth when taken for an extended period or in high doses.

Indication

It is used to treat the following disease conditions:

• Adrenal insufficiency and its associated conditions
• Bone and joint problems (Ex. rheumatoid arthritis, ankylosing spondylitis)
• Skin and collagen disorders (Ex. Stevens-Johnson syndrome, psoriasis)
• Problems of bowel and gut (Ex. Crohn’s disease and ulcerative colitis)
• Brain problems (Ex. tuberculous meningitis)
• Heart inflammation (Ex. endocarditis)
• Drug-induced hypersensitivity reactions
• Allergic reactions (such as atopic dermatitis, allergic conjunctivitis, and allergic rhinitis)
• Eye problems (Ex. optic neuritis, uveitis, or iritis)
• Respiratory tract diseases (Ex. asthma, tuberculosis, pneumonitis)
• Blood cancer (leukemia), lymph cancer (lymphoma)
• Anemia (low RBC count in the blood), thrombocytopenia (low platelet count in the blood)
• High blood calcium levels caused due to cancer treatment
• Protein loss via urine due to kidney problems

Pharmacology

Dexamethasone is a glucocorticoid medication that belongs to the class of corticosteroids. It works by suppressing the immune system and reducing inflammation in the body. One of its mechanisms of action is preventing the migration of leukocytes (a type of white blood cell) to sites of inflammation. It also reverses the enhanced permeability of capillaries, which can help reduce swelling and inflammation. By inhibiting the immune system's normal response, dexamethasone can effectively reduce inflammation in various conditions.

Dosage & Administration of Oradexon 0.5mg Tablet

Glucocorticoid dosages can vary depending on the severity of the condition and the individual response of the patient. Here are some general guidelines for oral dexamethasone dosages:

• For adult patients: The daily oral dosage typically ranges from 1 mg to 10 mg, based on the individual's response to the medication.
• For children: The daily oral dosage is usually between 0.03 mg/kg and 0.20 mg/kg of body weight, depending on the individual's response.
• In certain cases, higher dosages may be temporarily necessary to effectively control the disease. However, as soon as the circumstances allow, the dosage should be gradually decreased.
• A short dexamethasone suppression test may be conducted to assess the response. In this test, 1 mg of dexamethasone is given at 11 p.m., and the plasma cortisol level is measured the following morning.
• If there is no decrease in cortisol levels, a longer test may be performed. This involves administering 0.5 mg of dexamethasone every 6 hours for 48 hours, followed by 2 mg every 6 hours for an additional 48 hours. 24-hour urine collections are conducted before, during, and at the end of the test to measure 17 alpha-hydroxy corticoids.

It's important to note that these dosages and testing procedures are general guidelines, and individual patients may require different dosages based on their specific condition and response to treatment. The dosages should always be determined and adjusted by a healthcare professional.

Interaction

Oradexon 0.5mg Tablet may interact with the following drugs:

1. Aspirin: There may be an increased risk of gastrointestinal bleeding when dexamethasone is used concomitantly with aspirin.
2. Phenytoin and Carbamazepine: These anticonvulsant medications may decrease the effectiveness of dexamethasone.
3. Phenobarbital and Primidone: These sedative-hypnotic medications may increase the metabolism of dexamethasone, potentially reducing its effectiveness.
4. Rifampicin and Rifabutin: These antibiotics may increase the metabolism of dexamethasone, potentially reducing its effectiveness.
5. Aminoglutethimide and Methotrexate: These anticancer medications may increase the metabolism of dexamethasone, potentially reducing its effectiveness.
6. Warfarin: Dexamethasone may decrease the effectiveness of warfarin, leading to a decreased anticoagulant effect.
7. Ritonavir, Darunavir, and Indinavir: These antiretroviral drugs may affect the metabolism of dexamethasone, potentially altering its effectiveness.
8. Carbamazepine: Dexamethasone may decrease the effectiveness of carbamazepine.

Contraindications

• Gastric and duodenal ulcers.
• Systemic and ophthalmic fungal infections.
• Viral infections, e.g., varicella and herpes genitals infections. Viral infections of the eye.
• Glaucoma.
• Hypersensitivity to corticosteroids

Pregnancy & Lactation

Dexamethasone, the active ingredient in Oradexon 0.5mg Tablet, is classified as Pregnancy Category C. This means that there are no adequate and well-controlled studies on pregnant women, and its use during pregnancy should only be considered if the potential benefits outweigh the potential risks to the fetus.

It is also known that glucocorticoids, including dexamethasone, can pass into breast milk. Therefore, mothers who are taking high doses of corticosteroids are typically advised not to breastfeed to avoid potential adverse effects on the nursing infant.

It's important to consult with your healthcare provider if you are pregnant or breastfeeding and consider the use of Oradexon 0.5mg Tablet or any other medication. They can provide you with the most appropriate and up-to-date guidance based on your specific situation.

Precautions & Warnings

• It is important to inform your doctor about any allergies you have, including allergies to the ingredients of Oradexon 0.5mg Tablet  10's or sulfites. It is also important to disclose if you have received any live virus vaccines.
• Furthermore, it is crucial to discuss your medical history with your doctor, including any fungal infections, amoebiasis, myasthenia gravis, peptic ulcer, osteoporosis, psychoses, eye infections, glaucoma, mental conditions, tuberculosis (TB), bacteremia, joint conditions, liver conditions, kidney conditions, heart conditions, and septic arthritis resulting from gonorrhea or tuberculosis.
• If you are pregnant, planning to become pregnant, or breastfeeding, it is essential to inform your doctor before taking Oradexon 0.5mg Tablet 10's.
• During the course of Oradexon 0.5mg Tablet  10's therapy, if you experience mood changes, depression, or strange thoughts, it is important to notify your doctor immediately.

Storage Conditions

Store it at room temperature and away from moisture. Keep it out of reach of children and pets.